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Synjardy XR Price (empagliflozin and metformin hydrochloride extended-release)
Synjardy XR's U.S. list price is $1,050 for 90 days. In our latest check (Nov 11, 2026), none of the licensed pharmacies abroad we list sold brand Synjardy XR 25/1000 mg with a named maker, so the U.S. options below are the ones we can confirm.
- Lowest U.S. online pharmacy price
- $21.45 per tablet$1,930.67 for 90 days (90 tablets), shipping included · FDA-approved brand Synjardy XR 25/1000 mg · ships within the U.S.
- Lowest international online pharmacy price
- Not available
Generic empagliflozin and metformin hydrochloride extended-release 25/1000 mg (not FDA-approved · ships from India) from $187.71
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Name check: Synjardy (no XR) is a different, twice-daily tablet with other strengths. This page covers once-daily Synjardy XR only. Canada sells only Synjardy.
Compare Synjardy XR prices from licensed pharmacies
Recall notice: Boehringer Ingelheim Pharmaceuticals, Inc. is recalling some lots of Synjardy XR Tablets (empagliflozin and metformin hydrochloride extended-release tablets) (Class II, started Jun 12, 2026). Check your bottle's lot number against the FDA notice (recall number D-0657-2026), and ask your pharmacist if you have questions.
FDA sorts recalls into classes: Class I is the most serious and Class III the least.
For comparison U.S. pharmacy list price: $1,050 for 90 days ($11.67 per tablet), brand Synjardy XR 10/1000 mg or 25/1000 mg before insurance. The prices below are from U.S. pharmacies that publish cash prices and from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | Empagliflozin/Metformin XR 12.5mg/1000mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.12.5/1000 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Torrent Pharma Ltd | $95.83for 60 tablets$1.60 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $105.78 for 60 days= $158.67 for 90 daysWorked out from a 60-day orderChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy A | Empagliflozin/Metformin XR 25mg/1000mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.25/1000 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: MSN Lab | $115.19for 60 tablets$1.92 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $125.14 for 60 days= $187.71 for 90 daysSave 82%Worked out from a 60-day orderChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy B | Synjardy Xr, 12.5 MG - 1000 MG Extended Release Tablet (Prime member price)12.5 mg - 1000 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $179per 30 tablets · 3 packs = $537$5.97 per tablet | FreePharmacy's estimate: Usually next day | $537 for 90 days= $537 for 90 daysincl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy C | Synjardy XR 5-1000mg Tablet5/1000 mg · brandMaker listed by pharmacy: Boehringer Ingelheim Pharmaceuticals, Inc.Ships from United StatesShips within the U.S. (no customs) · checked Nov 5, 2026 | $583.20for 90 tablets$6.48 per tablet | $5Pharmacy's estimate: 2–8 business days | $588.20 for 90 days= $588.20 for 90 daysincl. $5 shippingChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy B | Synjardy Xr, 12.5 MG - 1000 MG Extended Release Tablet (price without insurance)12.5 mg - 1000 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $214.80per 30 tablets · 3 packs = $644.40$7.16 per tablet | Fee not publishedPharmacy's estimate: Usually next day | $644.40 for 90 days= $644.40 for 90 days+ shippingincl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy C | Synjardy XR 10-1000mg Tablet10/1000 mg · brandMaker listed by pharmacy: Boehringer Ingelheim Pharmaceuticals, Inc.Ships from United StatesShips within the U.S. (no customs) · checked Nov 5, 2026 | $1,105.20for 90 tablets$12.28 per tablet | $5Pharmacy's estimate: 2–8 business days | $1,110.20 for 90 days= $1,110.20 for 90 daysincl. $5 shippingChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy D | Empagliflozin/Metformin 25mg/1000mg Tablet (Cash price, 90-day supply)25/1000 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $1,930.67for 90 tablets$21.45 per tablet | FreePharmacy's estimate: 3–5 business days | $1,930.67 for 90 days= $1,930.67 for 90 daysincl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy D | Empagliflozin/Metformin 25mg/1000mg Tablet (Cash price, 30-day supply)25/1000 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $696.89per 30 tablets · 3 packs = $2,090.67$23.23 per tablet | FreePharmacy's estimate: 3–5 business days | $2,090.67 for 90 days= $2,090.67 for 90 daysincl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy E | Empagliflozin - Metformin XR 12.5mg/1000mg Tablet (Extended-Release)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.12.5/1000 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Cipla | $149.99for 100 tablets$1.50 per tabletOver 3-month supply | FreePharmacy's estimate: 2–3 weeks | $149.99 for 100 days= $134.99 for 90 daysWorked out from a 100-day orderChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy D | Empagliflozin/Metformin 25mg/1000mg Tablet (Cash price, 12-month (360-day) supply)25/1000 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $6,942.68for 360 tablets$19.29 per tabletOver 3-month supply | FreePharmacy's estimate: 3–5 business days | $6,942.68 for 360 days= $1,735.67 for 90 daysWorked out from a 360-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Synjardy XR from Canada?
90-day cost = 90 tablets at the usual dose of 1 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price of the same strength (10/1000 mg or 25/1000 mg); rows for other strengths show no saving. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, for whole fills, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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90-day prices from 1 licensed pharmacy abroad shipping to the U.S.: $158.67 to $187.71, any strength, shipping included.
Jump to: Medicare · Maker savings · Generic Synjardy XR · Similar drugs · Uses · FAQ
Synjardy XR (empagliflozin and extended-release metformin) for type 2 diabetes, 5/1000 to 25/1000 mg tablets taken once a day. No U.S. generic.
Synjardy XR price by strength
| Strength | Lowest brand90 days | Lowest generic abroad90 days, not FDA-approved | Price per tablet |
|---|---|---|---|
| Synjardy XR 12.5/1000 mg | — | $158.67 | $1.60 generic |
| Synjardy XR 25/1000 mg | — | $187.71 | $1.92 generic |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 11, 2026.
Cheapest ways to get Synjardy XR 25/1000 mg
The cheapest ways we found to get brand Synjardy XR 25/1000 mg (prices checked Nov 11, 2026). The lowest 90-day cost is shaded green.
| Way to buy | Cost | Details |
|---|---|---|
| U.S. pharmacy cash price | $1,930.67 for 90 days | FDA-approved brand Synjardy XR 25/1000 mg, ships within the U.S. (no customs). Shipping included, checked Nov 11, 2026. See all prices |
| U.S. list price | $1,050 for 90 days | Brand Synjardy XR before insurance. Pharmacies may charge more. |
| Maker’s patient assistance program | May be free if you qualify | Boehringer Ingelheim Cares Foundation Patient Assistance Program, checked Oct 29, 2026. Who qualifies |
| Medicare Part D | Depends on your plan | Your plan’s drug list and coverage phase set your cost. Medicare costs |
Costs abroad and at U.S. pharmacies are for one order closest to 90 days, shipping included, from the price table above. Programs set their own rules, so check the terms before you count on one.
How much does Synjardy XR cost without insurance?
Without insurance, Synjardy XR costs $350 for a 30-day supply at the U.S. list price, or about $1,050 for 90 days. Maker cash program: Boehringer Ingelheim DIRECT, the maker's cash-pay home delivery program, listed Jardiance but not Synjardy XR when we checked on October 26, 2026 (Boehringer Ingelheim).
Synjardy XR cost with Medicare
In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Synjardy XR depends on your plan's drug list and your coverage phase. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.
| Medicare Part D | What Synjardy XR costs | Source |
|---|---|---|
| Part D deductible (2026) | Up to $615 a year, depending on your plan | Medicare.gov |
| Yearly out-of-pocket cap (2026) | $2,100 for covered Part D drugs ($2,400 in 2027) | Medicare.gov |
Synjardy XR cost with insurance
With private or employer insurance, what you pay for Synjardy XR depends on your plan's drug list, deductible and copay. As little as $0 a month for a 30- to 90-day prescription with the Synjardy and Synjardy XR copay program, if eligible (monthly limits apply) (Boehringer Ingelheim).
Medicaid: Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office (Medicaid.gov).
Synjardy XR patient assistance program
Yes. Synjardy XR is offered through Boehringer Ingelheim Cares Foundation Patient Assistance Program, which can give the medicine at no cost to people who qualify. Who qualifies: U.S. residents with no health coverage or not enough coverage to get the medicine, with no other source of help, who meet BI Cares household income guidelines. It is free to apply. How to apply: Send the enrollment form (English or Spanish) by fax to 1-866-851-2827, or call 1-800-556-8317 (8:30 AM to 6 PM ET, Monday to Friday). (Checked 2026-10-29.)
Is there a generic Synjardy XR?
No. No generic Synjardy XR is sold in the U.S. The FDA Orange Book lists only Boehringer Ingelheim's Synjardy XR (NDA 208658) in all four strengths, with no approved generic.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 5/1000 mg | No | — | |
| 10/1000 mg | No | — | |
| 12.5/1000 mg | No | — | |
| 25/1000 mg | No | — |
Outside the U.S.: We found Synjardy XR only as a U.S. product. In our October 2026 check, we found no licensed online pharmacy abroad selling Synjardy XR.
Source: FDA Orange Book: Synjardy XR (NDA 208658). As of Oct 26, 2026.
Synjardy XR FAQ
How much does Synjardy XR cost without insurance?
The U.S. list price is $350 for a 30-day bottle, any strength, or $1,050 for a 90-day bottle (Boehringer Ingelheim's 2026 price before discounts, as reported to the Texas Department of State Health Services). Pharmacies may charge more. In our October 2026 check, we found no licensed online pharmacy abroad selling Synjardy XR. Synjardy XR was not part of Boehringer Ingelheim DIRECT, the maker's cash program, when we checked on October 26, 2026.
Why do some Synjardy XR bottles have 60 tablets?
In the U.S., the 5/1000 and 12.5/1000 mg tablets come in bottles of 60 and the 10/1000 and 25/1000 mg tablets in bottles of 30 (FDA NDC Directory). Boehringer Ingelheim's 2026 list price is $350 for each of these bottles. Compare prices for the same number of days, not the same number of tablets.
Is Synjardy XR covered by Medicare?
It depends on your Part D plan's drug list. In 2026, plans can have a deductible of up to $615, and out-of-pocket costs for covered drugs are capped at $2,100 a year ($2,400 in 2027). The maker's copay program can't be used with Medicare, but people with limited income can apply for Extra Help.
Is Synjardy XR sold in Canada?
We did not find it. Health Canada's Drug Product Database lists only Synjardy, the immediate-release tablet taken twice a day, from Boehringer Ingelheim (checked October 26, 2026). Synjardy is a different product from Synjardy XR, with different strengths.
Is there a generic Synjardy XR?
No. No generic Synjardy XR is sold in the U.S. The FDA Orange Book lists only Boehringer Ingelheim's Synjardy XR (NDA 208658) in all four strengths, with no approved generic.
Is there a patient assistance program for Synjardy XR?
Yes. Synjardy XR is offered through Boehringer Ingelheim Cares Foundation Patient Assistance Program, which can give the medicine at no cost to people who qualify. Who qualifies: U.S. residents with no health coverage or not enough coverage to get the medicine, with no other source of help, who meet BI Cares household income guidelines. It is free to apply. How to apply: Send the enrollment form (English or Spanish) by fax to 1-866-851-2827, or call 1-800-556-8317 (8:30 AM to 6 PM ET, Monday to Friday). (Checked 2026-10-29.)
What is the difference between Synjardy and Synjardy XR?
Both contain empagliflozin and metformin. Synjardy XR is an extended-release tablet taken once a day with the morning meal, in 5/1000, 10/1000, 12.5/1000 and 25/1000 mg. Synjardy is taken twice a day with meals and comes in 5/500, 5/1000, 12.5/500 and 12.5/1000 mg. Both have the same U.S. list price, $350 for a 30-day supply. See our Synjardy price page. Your prescriber decides which medicine is right for you.
Which is more expensive, Jardiance or Synjardy XR?
At U.S. list prices, a 30-day supply costs the same: $350 for 30 tablets of Jardiance and $350 for a 30-day bottle of Synjardy XR, in 2026. Boehringer Ingelheim DIRECT sells Jardiance for $249 per 30-day fill to people with no prescription coverage, but Synjardy XR is not in that cash program. See our Jardiance price page. Your prescriber decides which medicine is right for you.
Savings programs from the maker
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Synjardy XR coupons. These are the programs we could verify on the maker's and government sites:
- Synjardy and Synjardy XR Savings Card: for people 18 or older with commercial (private or employer) insurance in the 50 states, DC or Puerto Rico. Eligible patients may pay as little as $0 a month for a 30- to 90-day prescription, subject to monthly limits; the card re-enrolls you after 12 months if you still qualify. Not for prescriptions paid in part or full by Medicare, Medicaid, Medigap, VA, Department of Defense, TRICARE or other state or federal programs. Questions: 1-866-279-8990. (Synjardy savings)
- Boehringer Ingelheim Cares Foundation Patient Assistance Program: free Boehringer Ingelheim medicine for eligible U.S. residents who have no health coverage or not enough coverage for their medicine, have no other source of coverage or funding, and meet household income guidelines. Call 1-800-556-8317 to ask whether your medicine is covered and whether you qualify. (patient assistance program)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Compare Synjardy XR with similar drugs
Other type 2 diabetes medicines people often compare with Synjardy XR, including Synjardy (the twice-daily version) and Jardiance (empagliflozin alone). Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Synjardyempagliflozin and metformin hydrochloride | Type 2 diabetes medicine (SGLT2 inhibitor plus metformin) | $119.88 for 90 days | See prices |
| Jardianceempagliflozin | Diabetes, heart and kidney medicine (SGLT2 inhibitor) | $77.05 for 90 days | See prices |
| Glyxambiempagliflozin and linagliptin | Type 2 diabetes medicine (SGLT2 inhibitor plus DPP-4 inhibitor) | $131.92 for 90 days | See prices |
| Farxigadapagliflozin | Diabetes, heart and kidney medicine (SGLT2 inhibitor) | $53.09 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Synjardy XR used for?
Synjardy XR combines empagliflozin, an SGLT2 inhibitor, with extended-release metformin. According to its FDA label (prescribing information), it is used:
- Along with diet and exercise, to improve blood sugar control in adults with type 2 diabetes.
- In adults with type 2 diabetes, the empagliflozin in Synjardy XR is also used to lower the risk of cardiovascular death in people with heart disease, the risk of cardiovascular death and hospitalization in people with heart failure, and the risk of worsening kidney disease, kidney failure, cardiovascular death and hospitalization in people with chronic kidney disease.
Synjardy XR comes as 5/1000, 10/1000, 12.5/1000 and 25/1000 mg extended-release tablets (empagliflozin/metformin), taken once a day with the morning meal and swallowed whole. U.S. bottles of the 5/1000 and 12.5/1000 mg tablets hold 60 tablets for 30 days, and the 10/1000 and 25/1000 mg bottles hold 30. The label has a boxed warning about lactic acidosis, a rare but serious build-up of acid in the blood linked to metformin. It is only for type 2 diabetes and is not for people with severe kidney problems. Your prescriber decides which medicine is right for you.
Is it safe to order Synjardy XR from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress declared in FD&C Act 804(j)(1), 21 U.S.C. 384(j)(1), that enforcement against individuals should focus on imports posing a significant threat to public health. You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. Synjardy XR is a U.S. product: Health Canada's Drug Product Database lists only Synjardy (immediate-release, twice daily) from Boehringer Ingelheim, and in the U.K. and Europe Synjardy is also sold as immediate-release tablets. Those are different products from Synjardy XR.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Sources
- Texas DSHS: 2026 annual WAC report (drug price transparency) (Synjardy XR NDCs 00597-0280-73, -0290-74, -0295-88, -0300-45 (30-day bottles): $350.00 each; -0280-90, -0290-59, -0295-78, -0300-93 (90-day bottles): $1,050.00 each)
- FDA NDC Directory: Synjardy XR (NDA 208658) (bottles of 30/90 (10/1000, 25/1000 mg) and 60/180 (5/1000, 12.5/1000 mg); no DEA schedule)
- FDA label (FDALabel): SYNJARDY / SYNJARDY XR (effective 2026-08-25, version 23)
- DailyMed: Synjardy XR
- FDA Orange Book: Synjardy XR (NDA 208658) (no approved generic, checked 2026-10-26)
- Boehringer Ingelheim: Synjardy and Synjardy XR Savings Card (checked 2026-10-26)
- Boehringer Ingelheim DIRECT: available medicines (Synjardy XR not listed, checked 2026-10-26)
- Boehringer Cares Foundation Patient Assistance Program
- Wholesaler notice: Boehringer Ingelheim WAC reduction effective January 1, 2026 (Glyxambi, Jardiance, Synjardy, Synjardy XR, Trijardy XR; no amounts given)
- Health Canada Drug Product Database: SYNJARDY (only Synjardy (immediate-release) listed, no Synjardy XR, checked 2026-10-26)
- Medicare.gov: costs in drug plans (2026 deductible up to $615; out-of-pocket cap $2,100 in 2026, $2,400 in 2027)
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicaid.gov: cost sharing
- FDA: personal importation
- Boehringer Ingelheim: How much does JARDIANCE cost? (Jardiance list price $350, as of January 1, 2026)
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.
