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Myfembree Price (relugolix, estradiol and norethindrone acetate)
As of Nov 11, 2026, brand Myfembree 40/1/0.5 mg costs from $703.28 for 90 days at licensed pharmacies abroad (ships from UK; packs made for other countries are not FDA-approved), vs. $4,258.86 at the U.S. list price.
- U.S. list price
- $4,258.86 for 90 days (90 tablets)The maker's price for brand Myfembree before discounts · Source: Texas DSHS
- Lowest international online pharmacy price
- $5.27 per tablet$474.48 for 90 days (90 tablets), plus shipping (fee not published) · brand Myfembree 40/1/0.5 mg, not FDA-approved · ships from United Kingdom
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Name check: Ryeqo is the same tablet sold in the U.K. and Europe. Orgovyx contains relugolix alone (120 mg, for prostate cancer) and is a different medicine.
Compare Myfembree prices from licensed pharmacies
For comparison U.S. pharmacy list price: $4,258.86 for 90 days ($47.32 per tablet), brand Myfembree before insurance. The prices below are from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | Ryeqo 40mg/1mg/0.5mg Tablet (UK/EU pack, ships from United Kingdom)40/1/0.5 mg · brand · Filled in United KingdomMaker listed by pharmacy: Maker not shown by pharmacyMade for UK/EU | $442.85for 84 tablets$5.27 per tablet | Fee not publishedDelivery time not stated | $442.85 for 84 days= $474.48 for 90 days+ shippingSave 89%Worked out from an 84-day orderChecked Nov 7 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | Ryeqo (UK/EU pack, ships from United Kingdom)40/1/0.5 mg · brand · Filled in United KingdomProduct of UK/EU | $453.99for 84 tablets$5.40 per tablet | Fee not publishedDelivery time not stated | $453.99 for 84 days= $486.42 for 90 days+ shippingSave 89%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | MYFEMBREE40/1/0.5 mg · brand · Filled in UKProduct of UK | $656.39for 84 tablets$7.81 per tablet | FreeDelivery time not stated | $656.39 for 84 days= $703.28 for 90 daysSave 83%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Myfembree from Canada?
90-day cost = 90 tablets at the usual dose of 1 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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90-day prices from 1 licensed pharmacy shipping to the U.S.: $703.28, any strength, shipping included.
Jump to: Medicare · Maker savings · Generic Myfembree · Similar drugs · Uses · FAQ
Myfembree (relugolix, estradiol and norethindrone acetate) tablets for fibroid bleeding and endometriosis pain. No U.S. generic is sold yet.
Myfembree price by strength
| Strength | Lowest brand90 days | Price per tablet |
|---|---|---|
| Myfembree 40/1/0.5 mg | $703.28 | $7.81 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 11, 2026.
Cheapest ways to get Myfembree 40/1/0.5 mg
The cheapest ways we found to get brand Myfembree 40/1/0.5 mg (prices checked Nov 11, 2026). The lowest 90-day cost is shaded green.
| Way to buy | Cost | Details |
|---|---|---|
| Licensed online pharmacy abroad | $703.28 for 90 days | Brand Myfembree 40/1/0.5 mg, ships from UK, not FDA-approved (made for another country). Shipping included, checked Nov 11, 2026. See all prices |
| U.S. list price | $4,258.86 for 90 days | Brand Myfembree before insurance. Pharmacies may charge more. |
| Medicare Part D | Depends on your plan | Your plan’s drug list and coverage phase set your cost. Medicare costs |
Costs abroad and at U.S. pharmacies are for one order closest to 90 days, shipping included, from the price table above. Programs set their own rules, so check the terms before you count on one.
How much does Myfembree cost without insurance?
Without insurance, Myfembree costs $1,419.62 for a 30-day supply at the U.S. list price, or about $4,258.86 for 90 days. Licensed pharmacies abroad charged from $703.28 for 90 days of brand Myfembree 40/1/0.5 mg in our latest check (Nov 11, 2026), shipping included. Cash: The Myfembree copay program is not valid for cash-paying patients. We found no maker cash price (Sumitomo Pharma (myfembree.com)).
Myfembree cost with Medicare
In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Myfembree depends on your plan's drug list and your coverage phase. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.
| Medicare Part D | What Myfembree costs | Source |
|---|---|---|
| Part D deductible (2026) | Up to $615 a year, depending on your plan | Medicare.gov |
| Part D out-of-pocket cap (2026) | $2,100 a year for covered drugs | Medicare.gov |
| Limited income | Extra Help can lower what you pay for prescriptions | Social Security |
Myfembree cost with insurance
With private or employer insurance, what you pay for Myfembree depends on your plan's drug list, deductible and copay. As little as $5 per prescription for up to an 84-day supply with the Myfembree Copay Assistance Program, up to $5,000 in savings per calendar year (Sumitomo Pharma (myfembree.com)).
Medicaid: Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. The copay program can't be used with Medicaid (Medicaid.gov).
Myfembree patient assistance program
Sumitomo Pharma America runs Pfizer Patient Assistance Program (Pfizer RxPathways). Who qualifies: People who are uninsured, or have government insurance such as Medicare Part D or Medicare Advantage and can't afford their copay, with household income at or below 300% of the federal poverty level ($47,880 for 1 person or $99,000 for 4 in 2026). People with commercial insurance can't apply. You must live in the U.S. or a U.S. territory. People with Medicare must first enroll in the Medicare Prescription Payment Plan. We couldn't confirm on the program's own pages that Myfembree is on its current list (checked 2026-10-29), so call 1-844-989-7284 to ask before you apply.
Is there a generic Myfembree?
No. Myfembree is sold only as a brand in the U.S., by Sumitomo Pharma America. We found no generic version in the FDA's NDC Directory. The FDA Orange Book lists patents on Myfembree with expiration dates from 2029 to 2042. Patents can be challenged, so these dates don't tell you exactly when a generic will arrive.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 40/1/0.5 mg | No | — |
Outside the U.S.: The same tablet is sold as Myfembree in Canada and as Ryeqo in the U.K. and Europe (Gedeon Richter). Orgovyx contains relugolix alone and is a different medicine.
Source: FDA Orange Book: MYFEMBREE (NDA 214846). As of Oct 26, 2026.
Myfembree FAQ
How much does Myfembree cost without insurance?
The U.S. list price is $1,324.98 for a 28-tablet bottle, or $4,258.86 for 90 days (the maker's price before discounts, as reported to the Texas Department of State Health Services). As of Nov 11, 2026, brand Myfembree 40/1/0.5 mg cost from $703.28 for 90 days at licensed pharmacies abroad we compared, shipping included. The maker's copay program is not valid for cash-paying patients.
Is there a generic version of Myfembree?
No. Myfembree is sold only as a brand in the U.S., and we found no generic version in the FDA's drug listings. The FDA Orange Book lists patents on Myfembree with expiration dates from 2029 to 2042. The generic name is relugolix, estradiol and norethindrone acetate.
Does Medicare cover Myfembree?
It depends on your Part D plan. In 2026, the Part D deductible is up to $615 and out-of-pocket costs for covered drugs are capped at $2,100 a year. The Myfembree copay program can't be used with Medicare, but people with limited income can apply for Extra Help.
Can I buy Myfembree from Canada?
Myfembree is sold in Canada under the same name, and Ryeqo is the U.K. and European version. You need a prescription from your doctor, and U.S. import rules apply. Never buy it from a website that does not ask for a prescription.
Is there a patient assistance program for Myfembree?
Sumitomo Pharma America runs Pfizer Patient Assistance Program (Pfizer RxPathways). Who qualifies: People who are uninsured, or have government insurance such as Medicare Part D or Medicare Advantage and can't afford their copay, with household income at or below 300% of the federal poverty level ($47,880 for 1 person or $99,000 for 4 in 2026). People with commercial insurance can't apply. You must live in the U.S. or a U.S. territory. People with Medicare must first enroll in the Medicare Prescription Payment Plan. We couldn't confirm on the program's own pages that Myfembree is on its current list (checked 2026-10-29), so call 1-844-989-7284 to ask before you apply.
Is Ryeqo the same as Myfembree?
Ryeqo is the name used in the U.K. and Europe for the same combination: relugolix 40 mg, estradiol 1 mg and norethisterone acetate 0.5 mg (the European name for norethindrone acetate), marketed by Gedeon Richter. In the U.K. it is approved for uterine fibroid symptoms and endometriosis.
How long can a patient take Myfembree?
The FDA label limits use to 24 months in total, because Myfembree can cause bone loss that may not be fully reversible. Your prescriber decides which medicine is right for you.
Savings programs from the maker
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Myfembree coupons. These are the real savings programs, run by the drug's maker and by Medicare:
- Myfembree Copay Assistance Program: for people with commercial (private or employer) prescription insurance, age 18 or older, living in the U.S., Puerto Rico or U.S. territories. Eligible patients may pay as little as $5 per prescription for up to an 84-day supply, with a maximum of $5,000 in savings per calendar year. Valid for up to 12 fills of a 28-day supply or 4 fills of an 84-day supply. Not for Medicare, Medicaid, TRICARE, VA or other government programs, and not valid for cash-paying patients. Questions: 1-833-693-3627. (Program terms)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Compare Myfembree with similar drugs
Another women's health medicine on eDrugSearch: Slynd, a progestin-only birth control pill. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Slynddrospirenone | Birth control pill (progestin-only) | $133.73 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Myfembree used for?
Myfembree combines relugolix, a GnRH receptor antagonist, with estradiol (an estrogen) and norethindrone acetate (a progestin). According to its FDA label (DailyMed), it is used in premenopausal women for:
- Heavy menstrual bleeding caused by uterine fibroids (leiomyomas).
- Moderate to severe pain caused by endometriosis.
Myfembree is one tablet (relugolix 40 mg, estradiol 1 mg and norethindrone acetate 0.5 mg) taken once a day. The label limits use to 24 months because of the risk of bone loss that may not be reversible. Myfembree has a boxed warning, the FDA's strongest warning. Like other medicines that contain an estrogen and a progestin, it raises the risk of blood clots, stroke and heart attack, especially in women over 35 who smoke and women with high blood pressure that isn't controlled. The label says it must not be used by women who have or have had blood clots or who are at higher risk of them. Myfembree does not prevent pregnancy. Your prescriber decides which medicine is right for you.
Is it safe to order Myfembree from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Myfembree is sold under the same name (distributed by Pfizer Canada for Sumitomo Pharma); in the U.K. and Europe the same tablet is sold as Ryeqo.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Sources
- Texas Department of State Health Services: 2026 Annual WAC Report (Myfembree, NDC 72974-0415-01 (28 tablets): $1,324.98; checked October 26, 2026)
- Myfembree Copay Assistance Program: terms, conditions and eligibility (Sumitomo Pharma America) (checked October 26, 2026)
- MYFEMBREE U.S. prescribing information (DailyMed) (label revised September 2025)
- FDA Orange Book: MYFEMBREE (NDA 214846) patents (patents listed to November 5, 2042)
- FDA NDC Directory: relugolix products (Myfembree NDC 72974-415; no generic finished tablet found; checked October 26, 2026)
- Ryeqo 40 mg/1 mg/0.5 mg U.K. product information (emc) (Gedeon Richter Plc., PLGB 04854/0186)
- Health Canada: Regulatory Decision Summary, Myfembree (DIN 02541742)
- Medicare.gov: Part D costs (2026 deductible and out-of-pocket cap)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare.gov: Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.
