There are currently three main drugs used to treat osteoperosis: Boniva, Fosamax, and Actonel. All three drugs treat the disease in generally the same way, but do have slight differences that you may want to bring up when talking to your doctor. Lets take a look at a few of these differences and find out which drug best suites you.
The first drug on the market was Fosamax, follow by Actonel a few years later, then Boniva. Fosamax and Actonel are both taken weekly, while Boniva is taken monthly orally, and every three months intravenously. If taking medication is hard for you to remember or a hassle for you to keep up with, Boniva would be a good option.
Another thing to keep in mind is that after taking any of the medications, you must be on your feet for a period of time. Both Fosamax and Actonel, you must be standing for 30 minutes, where as Boniva requires you to be standing up for an hour. If you have a hard time staying on your feet for an extended period of time, you may want to consider Fosamax or Actonel.
All three drugs have FDA approval for the treatment and prevention of post-menopausal osteoporosis. Actonel has approval to reduce fractures at vertebral and nonvertebral sites (hip, wrist, pelvis, clavicle, leg, humorous), Fosamax at vertebral and hip, while Boniva has approval for the spine only.
Since there has been no clinical studies directly comparing all of the drugs, it is hard to say which one is statistically the best. All have been proven affective at treating osteoperosis, so I would talk it over with your doctor and weigh out the benefits of each before making a decision.212